Catalyst Biosciences To Present at the Ladenburg Thalmann 2016 Healthcare Conference
Ladenburg Thalmann 2016 Healthcare Conference – Catalyst Biosciences Presentation Details
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Location: Sofitel
About Hemophilia and Factor Replacement Therapy
Hemophilia, for which there is no cure, is a rare but serious bleeding disorder that results from a genetic or an acquired deficiency of a protein required for normal blood coagulation. There are two major types of hemophilia, A and B, that are caused by alterations in Factor VIII or Factor IX genes, respectively, with a corresponding deficiency in the affected proteins. The prevalence of hemophilia A and B in
About Marzeptacog alfa (activated) Factor VIIa
Marzeptacog alfa (formerly known as CB 813d) is a highly potent next-generation Factor VIIa that has successfully completed an IV Phase 1 clinical trial in individuals with severe hemophilia A and B both with and without inhibitors. Marzeptacog alfa (activated) was designed to combine higher clot-generating activity (high potency) at the site of bleeding and is being developed for the subcutaneous prophylaxis of individuals with severe hemophilia A and B with inhibitors.
About Factor IX
CB 2679d/ISU304 is a next-generation high potency coagulation Factor IX variant that is in advanced preclinical development. CB 2679d has exhibited enhanced procoagulant activity, improved efficacy in reducing blood loss, and prolonged duration of action in bleeding and non-bleeding preclinical models compared with other Factor IX products on the market and in development. Based on these findings, Catalyst believes that CB 2679d may allow for subcutaneous dosing in individuals with hemophilia B. Catalyst is developing CB 2679d in collaboration with
About Catalyst
Catalyst is a clinical-stage biopharmaceutical company focused on developing novel medicines to address hematology indications. Catalyst is focused on the field of hemostasis, including the subcutaneous prophylaxis of hemophilia and facilitating surgery in individuals with hemophilia. Catalyst’s most advanced program is an improved next-generation coagulation Factor VIIa variant, marzeptacog alfa (activated), that has successfully completed an intravenous Phase 1 clinical trial in individuals with severe hemophilia A and B. Catalyst is also developing a next-generation Factor IX variant, CB 2679d/ISU304, that is in advanced preclinical development. For more information, please visit www.catalystbiosciences.com.
Forward-Looking Statements
This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statement of historical facts, included in this press release regarding the Company’s product candidates, including product development plans for CB 2679d and marzeptacog alfa (activated), plans for and timing of clinical trials, and the potential uses of the Company’s product candidates are forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially from the forward-looking statements that the Company makes, including, but not limited to, the risk that trials and studies may be delayed and may not have satisfactory outcomes, potential adverse effects arising from the testing or use of the Company’s products, the risk that costs required to develop or manufacture the Company’s products will be higher than anticipated, risks related to the Company’s ability to protect or enforce intellectual property rights related to its product candidates, competition and other factors that affect the Company’s ability to establish collaborations on commercially reasonable terms and the Company’s ability to successfully develop and commercialize its product candidates. Other risks and uncertainties related to the Company’s business are described in the “Risk Factors” section of the Company’s Annual Report on Form 10-K and Quarterly Report on Form 10-Q filed with the
Investors:Andrew McDonald Managing DirectorLifeSci Advisors, LLC +1.646.597.6987 andrew@lifesciadvisors.comFletcher Payne , CFOCatalyst Biosciences, Inc. +1.650.871.0761 investors@catbio.com Media:Denise Powell Red House Consulting, LLC +1.510.703.9491 denise@redhousecomms.com