October 24, 2023
 
VIA EDGAR
 
U.S. Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, DC 20549

Attention:
Jason Drory and Laura Crotty


Re:
Catalyst Biosciences, Inc.
Registration Statement on Form S-3 (File No. 333-273395)
 
Ladies and Gentlemen:

Catalyst Biosciences, Inc. hereby respectfully requests that, pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, the effectiveness of the above-referenced Registration Statement on Form S-3 be accelerated so that it will become effective on October 27, 2023, at 9:00 a.m., Eastern Time, or as soon as practicable thereafter, unless we or our outside counsel, Orrick, Herrington & Sutcliffe LLP, request by telephone that such Registration Statement be declared effective at some other time.
 
We request that we be notified of such effectiveness by a telephone call to Stephen Thau of Orrick, Herrington & Sutcliffe LLP at (212) 506-5076.

 
 
Sincerely,
 
 
 
 
 
 
CATALYST BIOSCIENCES, INC.
 
 
 
 
 
 
By:
/s/ Nassim Usman
 
 
 
Nassim Usman, Ph.D.
 
 
 
President and Chief Executive Officer

cc:
Stephen Thau, Orrick, Herrington & Sutcliffe LLP