Entity Central Index Key
Accumulated gross unrealized gain before tax available for sale securities.
Sale securities available.
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Current Reporting Status
Entity Current Reporting Status
Entity Voluntary Filers
Entity Voluntary Filers
Entity Filer Category
Entity Filer Category
Entity Shell Company
Entity Shell Company
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Public Float
Entity Public Float
ICFR Auditor Attestation Flag
Icfr Auditor Attestation Flag
Entity Interactive Data Current
Entity Interactive Data Current
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Entity File Number
Entity File Number
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Auditor Firm ID
Auditor Firm Id
Auditor Name
Auditor Name
Auditor Location
Auditor Location
Statement Of Financial Position [Abstract]
Assets
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Short-term investments
Short Term Investments
Accounts receivable
Accounts Receivable Net Current
Prepaid and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Long-term investments
Long Term Investments
Other assets, noncurrent
Other Assets Noncurrent
Right-of-use assets
Operating Lease Right Of Use Asset
Property and equipment, net
Property Plant And Equipment Net
Total assets
Assets
Liabilities and stockholders’ equity
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued compensation
Accrued Employee Benefits Current
Deferred revenue
Deferred Revenue Current
Other accrued liabilities
Other Accrued Liabilities Current
Operating lease liability
Operating Lease Liability Current
Total current liabilities
Liabilities Current
Operating lease liability, noncurrent
Operating Lease Liability Noncurrent
Total liabilities
Liabilities
Commitments and Contingencies (Note 7)
Commitments And Contingencies
Stockholders’ equity:
Stockholders Equity [Abstract]
Preferred stock, $0.001 par value, 5,000,000 shares authorized; zero shares issued and outstanding
Preferred Stock Value
Common stock, $0.001 par value, 100,000,000 shares authorized; 31,409,707 and 22,097,820 shares issued and outstanding at December 31, 2021 and 2020, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital
Accumulated other comprehensive income
Accumulated Other Comprehensive Income Loss Net Of Tax
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders’ equity
Stockholders Equity
Total liabilities and stockholders’ equity
Liabilities And Stockholders Equity
Preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, shares issued
Preferred Stock Shares Issued
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Interest and other income (expense), net.
Income Statement [Abstract]
Statement [Table]
Statement [Table]
Product and Service
Product Or Service [Axis]
Product and Service
Products And Services [Domain]
License revenue member.
License
License Revenue [Member]
Collaboration revenue member.
Collaboration
Collaboration Revenue [Member]
Cost of license member.
Cost of license
Cost Of License [Member]
Cost of collaboration.
Cost of collaboration
Cost Of Collaboration [Member]
Statement [Line Items]
Statement [Line Items]
Revenue:
Revenues [Abstract]
License and collaboration revenue
Revenue From Contract With Customer Excluding Assessed Tax
Operating expenses:
Operating Expenses [Abstract]
Cost of license and collaboration
Cost Of Goods And Services Sold
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Total operating expenses
Operating Expenses
Loss from operations
Operating Income Loss
Interest and other income (expense), net
Interest And Other Income Expense Net
Net loss
Net Income Loss
Net loss per share attributable to common stockholders, basic and diluted
Earnings Per Share Basic And Diluted
Shares used to compute net loss per share attributable to common stockholders, basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Statement Of Income And Comprehensive Income [Abstract]
Net loss
Other comprehensive loss:
Other Comprehensive Income Loss Net Of Tax Period Change [Abstract]
Unrealized loss on available-for-sale debt securities
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
Total comprehensive loss
Comprehensive Income Net Of Tax
Stock issued during period from ESPP purchases and stock options exercised value.
Stock issued during period from ESPP purchases and stock options exercised shares.
Statement Of Stockholders Equity [Abstract]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock
Common Stock [Member]
Additional Paid-In Capital
Additional Paid In Capital [Member]
Accumulated Other Comprehensive Income (Loss)
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit
Retained Earnings [Member]
Class of Stock
Statement Class Of Stock [Axis]
Class of Stock
Class Of Stock [Domain]
Convertible Preferred Stock
Convertible Preferred Stock [Member]
Balance
Balance (in shares)
Shares Outstanding
Stock-based compensation expense
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Stock-based compensation expense
Stock Issued During Period Shares Share Based Compensation
Issuance of common stock from ESPP purchases and stock option exercises
Stock Issued During Period From E S P P Purchases And Stock Options Exercised Value
Issuance of common stock from ESPP purchases and stock option exercises, shares
Stock Issued During Period From E S P P Purchases And Stock Options Exercised Shares
Issuance of common stock for public offering, net of issuance costs
Stock Issued During Period Value New Issues
Issuance of common stock for public offering, net of issuance costs, shares
Stock Issued During Period Shares New Issues
Balance
Balance (in shares)
Issuance costs of issuance of common stock for public offering
Adjustments To Additional Paid In Capital Stock Issued Issuance Costs
Increase Decrease in operating lease liability and right-of-use asset.
Payments to acquire short term and long investments.
Proceeds from issuance of common stock for secondary public offering, net of issuance costs.
Proceeds from issuance of common stock from ESPP purchases and stock option exercises.
Right-of-use assets obtained in exchange for operating lease liabilities.
Remeasurement of right-of-use asset due to operating lease modification.
Statement Of Cash Flows [Abstract]
Operating Activities
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Stock-based compensation expense
Share Based Compensation
Depreciation and amortization
Depreciation Depletion And Amortization
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Accounts receivable
Increase Decrease In Accounts Receivable
Prepaid and other assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Accounts payable
Increase Decrease In Accounts Payable
Accrued compensation and other accrued liabilities
Increase Decrease In Accrued Liabilities
Operating lease liability and right-of-use asset
Increase Decrease In Operating Lease Liability And Right Of Use Asset
Deferred revenue
Increase Decrease In Contract With Customer Liability
Net cash flows used in operating activities
Net Cash Provided By Used In Operating Activities
Investing Activities
Net Cash Provided By Used In Investing Activities [Abstract]
Proceeds from maturities of short-term investments
Proceeds From Sale Maturity And Collection Of Shortterm Investments
Purchase of short-term and long-term investments
Payments To Acquire Short Term And Long Investments
Purchases of property and equipment
Payments To Acquire Investments
Net cash flows provided by investing activities
Net Cash Provided By Used In Investing Activities
Financing Activities
Net Cash Provided By Used In Financing Activities [Abstract]
Issuance of common stock for public offering, net of issuance costs
Proceeds From Issuance Of Common Stock For Public Offering Net Of Issuance Costs
Issuance of common stock from ESPP purchase and stock option exercises
Proceeds From Issuance Of Common Stock From E S P P Purchases And Stock Option Exercises
Net cash flows provided by financing activities
Net Cash Provided By Used In Financing Activities
Net increase in cash and cash equivalents
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash and cash equivalents at beginning of the period
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
Cash and cash equivalents at end of the period
Supplemental Disclosure of Non-Cash Investing and Financing Activities:
Noncash Investing And Financing Items [Abstract]
Right-of-use assets obtained in exchange for operating lease liabilities
Non Cash Or Part Non Cash Right Of Use Assets Obtained In Exchange For Operating Lease Liabilities
Remeasurement of right-of-use asset due to operating lease modification
Non Cash Or Part Non Cash Remeasurement Of Right Of Use Asset Due To Operating Lease Modification
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Nature of Operations
Nature Of Operations
Liquidity
Liquidation Basis Of Accounting [Text Block]
Accounting Policies [Abstract]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Fair Value Disclosures [Abstract]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Investments All Other Investments [Abstract]
Financial Instruments
Financial Instruments Disclosure [Text Block]
Payables And Accruals [Abstract]
Other Accrued Liabilities
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments Disclosure [Text Block]
Related Party Transactions [Abstract]
Related Parties
Related Party Transactions Disclosure [Text Block]
Lessee Disclosure [Abstract]
Leases
Lessee Operating Leases [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Stock Based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Collaborations
Collaborative Arrangement Disclosure [Text Block]
Other Income And Expenses [Abstract]
Interest and Other Income (Expense), Net
Interest And Other Income [Text Block]
Equity [Abstract]
Stockholders' Equity
Stockholders Equity Note Disclosure [Text Block]
Earnings Per Share [Abstract]
Net Loss per Share Attributable to Common Stockholders
Earnings Per Share [Text Block]
Restructuring And Related Activities [Abstract]
Restructuring
Restructuring And Related Activities Disclosure [Text Block]
Subsequent Events [Abstract]
Subsequent Event
Subsequent Events [Text Block]
Basis of Presentation
Basis Of Accounting Policy Policy [Text Block]
Use of Estimates
Use Of Estimates
Accounting Pronouncements Recently Adopted
New Accounting Pronouncements Policy Policy [Text Block]
Cash and Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Fair Value of Financial Instruments
Fair Value Of Financial Instruments Policy
Property and Equipment
Property Plant And Equipment Policy [Text Block]
Investments
Marketable Securities Policy
Revenue Recognition
Revenue Recognition Policy [Text Block]
Cost of license and collaboration revenue policy.
Cost of License and Collaboration Revenue
Cost Of License And Collaboration Revenue Policy [Text Block]
Research and Development Expenses
Research And Development Expense Policy
Accrued research and development expenses.
Accrued Research and Development Expenses
Accrued Research And Development Expenses Policy [Text Block]
Concentration Risk Credit Risk
Concentration Risk Credit Risk
Concentration Risk Credit Risk Policy [Text Block]
Accounts Receivable, net and Allowance for Doubtful Accounts
Receivables Trade And Other Accounts Receivable Allowance For Doubtful Accounts Policy
Income Taxes
Income Tax Policy [Text Block]
Stock-Based Compensation
Share Based Compensation Option And Incentive Plans Policy
Restructuring Charges
Costs Associated With Exit Or Disposal Activities Or Restructurings Policy
Leases
Lessee Leases Policy [Text Block]
Net Loss per Share
Earnings Per Share Policy [Text Block]
Assets and Liabilities Measured at Fair Value on a Recurring Basis
Fair Value Assets Measured On Recurring Basis [Text Block]
Sale securities available text block.
Cash Equivalents, Restricted Cash and Short-Term Investments Classified as Available-for-sale Securities
Sale Securities Available [Text Block]
Schedule of Other Accrued Liabilities
Schedule Of Accrued Liabilities Table [Text Block]
Summary of present value assumptions of lease payments.
Summary of Present Value Assumptions used in Calculating Present Value of Lease Payments
Summary Of Present Value Assumptions Of Lease Payments Table [Text Block]
Schedule of Maturity of Operating Lease Liabilities
Lessee Operating Lease Liability Maturity Table [Text Block]
Schedule of Supplemental Cash Flow Information
Schedule Of Cash Flow Supplemental Disclosures Table [Text Block]
Summary of Option Activity Under Company's Equity Incentive Plans
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Summary of Weighted Average Valuation Assumptions Used to Estimate Fair Value of Employee Stock Options
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Summary of Stock-Based Compensation Recognized
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Reconciliation of Federal Income Tax Rate to Company's Effective Tax Rate
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Components of the Company's Deferred Tax Assets (Liabilities)
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Unrecognized Tax Benefits
Schedule Of Unrecognized Tax Benefits Roll Forward Table [Text Block]
Detail of Interest and Other Income (Expense), Net
Schedule Of Other Nonoperating Income Expense Table [Text Block]
Anti-dilutive Security not Included in Diluted per Share Calculations
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Summary of Restructuring Charges Recorded in Component of Operating Expenses
Schedule Of Restructuring And Related Costs [Text Block]
Number of operating segment
Number Of Operating Segments
Liquidity.
Liquidity [Abstract]
Accumulated deficit
Cash, cash equivalents and short-term investments
Cash Cash Equivalents And Short Term Investments
Net loss
Summary of significant accounting policies.
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Accounting Standards Update
Adjustments For New Accounting Pronouncements [Axis]
Accounting Standards Update
Type Of Adoption [Member]
AS 2016-02
Accounting Standards Update201602 [Member]
Long-Lived Tangible Asset
Property Plant And Equipment By Type [Axis]
Long-Lived Tangible Asset
Property Plant And Equipment Type [Domain]
Computer equipment
Computer Equipment [Member]
Furniture
Furniture And Fixtures [Member]
Leasehold improvements
Leasehold Improvements [Member]
Finite-Lived Intangible Assets by Major Class
Finite Lived Intangible Assets By Major Class [Axis]
Finite-Lived Intangible Assets, Major Class Name
Finite Lived Intangible Assets Major Class Name [Domain]
Software
Computer Software Intangible Asset [Member]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Minimum
Minimum [Member]
Maximum
Maximum [Member]
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development Expense
Research And Development Expense [Member]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Lease practical expedients
Lease Practical Expedients Package
Estimated useful lives
Property Plant And Equipment Useful Life
Cost of collaboration revenue.
Cost of collaboration revenue
Cost Of Collaboration Revenue
Accounts receivable
Accounts Receivable Gross Current
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Investment Type
Investment Type [Axis]
Investments
Investment Type Categorization [Member]
Long term investments.
Long Term Investments
Long Term Investments [Member]
Asset Class
Fair Value By Asset Class [Axis]
Asset Class
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain]
U.S. Government Agency Securities
U S Government Agencies Debt Securities [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Available-for-sale, debt securities
Available For Sale Securities Debt Securities
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Fair Value, Inputs, Level 1
Fair Value Inputs Level1 [Member]
Fair Value, Inputs, Level 2
Fair Value Inputs Level2 [Member]
Fair Value, Inputs, Level 3
Fair Value Inputs Level3 [Member]
Cash and Cash Equivalents
Cash And Cash Equivalents [Axis]
Cash and Cash Equivalents
Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member]
Money Market Funds
Money Market Funds [Member]
Federal Agency Securities
U S Government Sponsored Enterprises Debt Securities [Member]
Short-Term Investments
Short Term Investments [Member]
Assets, fair value
Assets Fair Value Disclosure
Amortized cost available for sale securities.
Investments Debt And Equity Securities [Abstract]
Schedule Of Available For Sale Securities [Table]
Schedule Of Available For Sale Securities [Table]
Cash and Cash Equivalents
Cash And Cash Equivalents [Member]
Cash Equivalents
Cash Equivalents [Member]
Financial Instrument
Financial Instrument [Axis]
Financial Instruments
Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain]
Federal agency securities.
Federal Agency Securities
Federal Agency Securities [Member]
Other Long-term Investments
Other Long Term Investments [Member]
Schedule Of Available For Sale Securities [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost
Amortized Cost Available For Sale Securities
Gross Unrealized Gains
Accumulated Gross Unrealized Gain Before Tax Available For Sale Securities
Gross Unrealized Losses
Available For Sale Securities Accumulated Gross Unrealized Loss Before Tax
Estimated Fair Value
Sale Securities Available
Gross realized gain loss net available for sales securities.
Available for sale debt securities contractual maturity.
Financial instrument.
Financial instruments.
Financial Instruments [Table]
Financial Instruments [Table]
Financial Instrument [Line Items]
Financial Instrument [Line Items]
Material realized gains or losses on available-for-sale securities
Gross Realized Gain Loss Net Available For Sales Securities
Available-for-sale debt securities current
Available For Sale Securities Debt Securities Current
Available for sale debt securities contractual maturities
Available For Sale Debt Securities Contractual Maturity
Accrued manufacturing expenses current.
Accrued collaboration expenses current.
Accrued Pre Clinical Expenses Current.
Accrued clinical expenses current.
Accrued and other current liabilities.
Manufacturing
Accrued Manufacturing Expenses Current
Biogen
Accrued Collaboration Expenses Current
Pre-clinical
Accrued Pre Clinical Expenses Current
Professional and consulting services
Accrued Professional Fees Current
Clinical
Accrued Clinical Expenses Current
Other
Accrued And Other Current Liabilities
Total other accrued liabilities
Firm work order supporting clinical trials.
Cost of services as per agreement.
Cost of manufacturing services related company.
Charges related to write off of prepaid manufacturing costs.
Commitments and contingencies disclosure.
Commitments and contingencies disclosure.
Commitments And Contingencies Disclosure [Table]
Commitments And Contingencies Disclosure [Table]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
AGC Biologics Inc.
AGC Biologics, Inc
A G C Biologics Inc [Member]
Marzeptacog alfa (activated).
Marzeptacog Alfa Activated
Marzeptacog Alfa Activated [Member]
Integrity bio .
Catalent Indiana, LLC.
Integrity Bio [Member]
Marzeptacog alfa activated and dalcinonacog alfa.
Marzeptacog Alfa Activated and Dalcinonacog Alfa
Marzeptacog Alfa Activated And Dalcinonacog Alfa [Member]
Dalcinonacog alfa.
Dalcinonacog Alfa
Dalcinonacog Alfa [Member]
GMP manufacturing.
Dalcinonacog alfa.
G M P [Member]
Service Agreements
Service Agreements [Member]
Commitments And Contingencies Disclosure [Line Items]
Commitments And Contingencies Disclosure [Line Items]
Firm work order supporting clinical trials
Firm Work Order Supporting Clinical Trials
Cost of services as per agreement
Cost Of Services As Per Agreement
Cost of Manufacturing Services
Cost Of Manufacturing Services
Contractual obligation payments
Contractual Obligation
Charges related to write off of prepaid manufacturing cost
Charges Related To Write Off Of Prepaid Manufacturing Cost
Upfront fee reveived from license and collaboration agreement.
Sublicense fee entitled to pay.
Milestone payment .
Schedule Of Related Party Transactions By Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Related Party
Related Party Transactions By Related Party [Axis]
Related Party
Related Party [Domain]
Mosaic Biosciences, Inc.
Mosaic Biosciences Inc
Mosaic Biosciences Inc [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Biogen collaboration.
Biogen Collaboration
Biogen Collaboration [Member]
Intravitreal anti-complement factor 3.
Intravitreal Anti-Complement Factor 3
Intravitreal Anti Complement Factor3 [Member]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Upfront license fee received from collaboration agreement
Upfront Fee Reveived From License And Collaboration Agreement
Payment related to collaboration
Sublicense Fee
One Time Expense related to collaboration
Related Party Transaction Expenses From Transactions With Related Party
Milestone Payment Related To Regulatory And Clinical Development Events
Milestone Payment Related To Regulatory And Clinical Development Events
Lessee operating lease renewal term description.
Lessee Lease Description [Table]
Lessee Lease Description [Table]
Lease lab and office space.
Lease Lab And Office Space
Lease Lab And Office Space [Member]
Sublease arrangement.
Sublease Arrangement
Sublease Arrangement [Member]
Lessee Lease Description [Line Items]
Lessee Lease Description [Line Items]
Lease expiration date
Lease Expiration Date1
Lessee operating lease renewal term description
Lessee Operating Lease Renewal Term Description
Right-of-use asset and lease liability
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
Undiscounted future payment
Lessee Operating Lease Liability Payments Due
Operating lease, option to extend
Lessee Operating Lease Option To Extend
Operating lease commenced description
Lessee Operating Lease Description
Operating lease not yet commenced description
Lessee Operating Lease Lease Not Yet Commenced Description
Operating lease term of contract
Lessee Operating Lease Term Of Contract
Operating lease expense
Operating Lease Expense
Weighted-average remaining lease term
Operating Lease Weighted Average Remaining Lease Term1
Weighted-average discount rate
Operating Lease Weighted Average Discount Rate Percent
Operating Lease Liabilities Payments Due [Abstract]
2022
Lessee Operating Lease Liability Payments Due Next Twelve Months
2023
Lessee Operating Lease Liability Payments Due Year Two
Total undiscounted lease payments
Less: imputed interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Total operating lease liability
Operating Lease Liability
Cash paid for amounts included in the measurement of lease liabilities.
Prepaid Cash Payment For Lease Liabilities.
Cash paid for amounts included in the measurement of lease liabilities
Cash Paid For Amounts Included In The Measurement Of Lease Liabilities
Prepaid cash payment for lease
Prepaid Cash Payment For Lease Liabilities
Cash paid for operating leases that were included in operating cash outflows
Operating Lease Payments
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two thousand eighteen omnibus incentive plan.
2018 Omnibus Incentive Plan
Two Thousand Eighteen Omnibus Incentive Plan [Member]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Performance based stock option grants.
Performance Based Stock Option Grants
Performance Based Stock Option Grants [Member]
Employee Stock Option
Employee Stock Option [Member]
Two thousand eighteen employee stock purchase plan.
2018 Employee Stock Purchase Plan
Two Thousand Eighteen Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase in number of shares of common stock reserved for issuance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Period Increase Decrease
Common Stock, Capital Shares Reserved for Future Issuance
Common Stock Capital Shares Reserved For Future Issuance
Issuance of option grants to purchase common stock shares.
Issuance of option grants to purchase common stock shares
Issuance Of Option Grants To Purchase Common Stock Shares
Number of Shares Underlying Outstanding Options
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward
Number of Shares Underlying Outstanding Options, Beginning Balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Number of Shares Underlying Outstanding Options, Options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Number of Shares Underlying Outstanding Options, Options exercised
Stock Issued During Period Shares Stock Options Exercised
Number of Shares Underlying Outstanding Options, Options forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Number of Shares Underlying Outstanding Options, Options expired
Share Based Compensation Arrangement By Share Based Payment Award Options Expirations In Period
Number of Shares Underlying Outstanding Options, Ending Balance
Number of Shares Underlying Outstanding Options, Exercisable- December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Shares available to be granted - December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Weighted- Average Exercise Price
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward
Weighted- Average Exercise Price, Beginning Balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Weighted- Average Exercise Price, Options granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Weighted- Average Exercise Price, Options exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Weighted- Average Exercise Price, Options forfeited
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Weighted- Average Exercise Price, Options expired
Share Based Compensation Arrangements By Share Based Payment Award Options Expirations In Period Weighted Average Exercise Price
Weighted- Average Exercise Price, Ending Balance
Weighted- Average Exercise Price, Exercisable - December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Weighted-Average Remaining Contractual Term (Years)
Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract]
Weighted-Average Remaining Contractual Term (Years), Outstanding Balance
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Weighted Average Remaining Contractual Term, Exercisable - December 31, 2020
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Additional General Disclosures [Abstract]
Aggregate Intrinsic Value, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Weighted average grant date fair value of stock options
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Aggregate intrinsic value of options exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Fair value of options vested
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested In Period Fair Value1
Share based compensation arrangement by share based payment award fair value assumptions Black-Scholes method used.
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Black-Scholes Method Used [Table]
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Black Scholes Method Used [Table]
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Black Scholes Method Used [Table]
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Black Scholes Method Used [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Black Scholes Method Used [Line Items]
Expected term (in years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Research and development
General and Administrative
General And Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation
Allocated Share Based Compensation Expense
Number of shares of common stock issued to certain board members in lieu of cash compensation
Stock Issued During Period Shares Issued For Services
Unrecognized employee stock based compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Unrecognized employee stock based compensation expense, period for recognition
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Percentage of fair market value of common stock
Sharebased Compensation Arrangement By Sharebased Payment Award Purchase Price Of Common Stock Percent
Maximum employee subscription rate
Share Based Compensation Arrangement By Share Based Payment Award Maximum Employee Subscription Rate
Number of common stock available for future grant
Number of common stock authorized for issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Number of common stock stock issued
Share Based Compensation Arrangement By Share Based Payment Award Shares Issued In Period
Proceeds from Issuance
Proceeds From Issuance Or Sale Of Equity
Effective income tax rate reconciliation, permanent differences.
Effective income tax rate reconciliation derecognition.
Tax at statutory federal rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
State Tax (benefit)—net of federal benefit
Effective Income Tax Rate Reconciliation State And Local Income Taxes
Permanent differences
Effective Income Tax Rate Reconciliation Permanent Differences
Tax credits
Effective Income Tax Rate Reconciliation Tax Credits
Derecognition due to Sec. 382 and 383 limitations
Effective Income Tax Rate Reconciliation Derecognition
Change in valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Other
Effective Income Tax Rate Reconciliation Nondeductible Expense Other
Effective tax rate
Effective Income Tax Rate Continuing Operations
Deferred tax assets fixed assets and intangibles.
Deferred tax assets:
Deferred Tax Assets Gross [Abstract]
Accruals and reserves
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals
Net operating loss carry forwards
Deferred Tax Assets Operating Loss Carryforwards
Tax credit carry forwards
Deferred Tax Assets Tax Credit Carryforwards Research
Fixed and intangible assets
Deferred Tax Assets Fixed Assets And Intangibles
Valuation allowance
Deferred Tax Assets Valuation Allowance
Net deferred tax assets:
Deferred Tax Assets Net
Income Tax.
Income Tax [Table]
Income Tax [Table]
Income Tax [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Federal Income Tax
Domestic Country [Member]
State Income Tax
State And Local Jurisdiction [Member]
CALIFORNIA
CALIFORNIA
Income Tax [Line Items]
Income Tax [Line Items]
Increase (decrease) in valuation allowance
Valuation Allowances And Reserves Period Increase Decrease
Operating loss carryforwards expiration year.
Operating loss carryforwards with indefinite life.
Net operating loss carryforwards
Operating Loss Carryforwards
Net operating loss carryforwards expiration year
Operating Loss Carryforwards Expiration Year
Net operating loss carryforwards having indefinite life
Operating Loss Carryforwards With Indefinite Life
Tax credit carryforwards available to offset future federal tax liabilities
Tax Credit Carryforward Amount
Credit carryforward, expire period
Tax Credit Carryforward Expiration Date
Deferred tax assets state net operating loss carry forwards.
Net operating loss carryforward, derecognized
Deferred Tax Assets State Net Operating Loss Carry Forwards
Research and development tax credit carry forwards derecognized.
Gross federal R&D tax credit-related deferred tax assets derecognized
Research And Development Tax Credit Carry Forwards Derecognized
Maximum amount of tax offset per year.
The minimum taxable income required to support realizing the company's.
Maximum amount of tax offset per year
Maximum Amount Of Tax Offset Per Year
Required Minimum Taxable Income
Required Minimum Taxable Income
Unrecognized tax benefit
Unrecognized Tax Benefits
Unrecognized tax benefits increase (decrease) resulting from tax positions.
Beginning Balance
Increase/(Decrease) of unrecognized tax benefits taken in prior years
Unrecognized Tax Benefits Increase Decrease Resulting From Prior Period Tax Positions
Increase/(Decrease) of unrecognized tax benefits related to current year
Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions
Ending Balance
Tax-related penalties or interest recognized
Income Tax Examination Penalties And Interest Accrued
Uncertain tax positions
Liability For Uncertain Tax Positions Current
Milestone payments.
Regulatory and development milestone payment.
Commercial milestone payments.
Collaboration agreements.
Collaboration Agreements [Abstract]
Revenue Recognition Multiple Deliverable Arrangements [Table]
Revenue Recognition Multiple Deliverable Arrangements [Table]
ISU Abxis.
ISU Abxis
Isu Abxis [Member]
Transaction Type
Transaction Type [Axis]
Transaction
Transaction [Domain]
Amended and restated license agreement.
Amended and Restated License Agreement
Amended And Restated License Agreement [Member]
Biogen.
Biogen
Biogen [Member]
License and Collaboration Agreement (the “Biogen Agreement”), .
License and Collaboration Agreement (the “Biogen Agreement”)
License And Collaboration Agreement [Member]
Exclusive license.
Exclusive License
Exclusive License [Member]
Exclusive License
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others By Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others Type [Domain]
Transfer of Exclusive License and Related Know-How.
Transfer of Exclusive License and Related Know-How
Transfer Of Exclusive License And Related Know How [Member]
Collaboration
Reimbursable Out-of-Pocket and Personnel Costs Incurred Related to Research Services.
Reimbursable Out-of-Pocket and Personnel Costs Incurred Related to Research Services
Reimbursable Out Of Pocket And Personnel Costs Incurred Related To Research Services [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Milestone payment
Milestone Payments
Regulatory and development milestone payment
Regulatory And Development Milestone Payment
Commercial milestone payments
Commercial Milestone Payments
Research services.
Research services agreement option to extend.
Research services
Research Services Agreement Term
Research services option to extend
Research Services Agreement Option To Extend
Development milestones payment Receivable.
Up-front payments received
Proceeds From License Fees Received
Development and sales milestone payments
Development Milestones Payment Receivable
Deferred revenue, recognized
Deferred Revenue Revenue Recognized1
Miscellaneous income (expense).
Interest income
Interest Income Expense Nonoperating Net
Miscellaneous income
Miscellaneous Income Expense
Other
Other Nonoperating Income Expense
Total interest and other income (expense), net
Underwriting commissions and offering expenses payable.
Stockholders equity disclosure.
Stockholders equity disclosure.
Stockholders Equity Disclosure [Table]
Stockholders Equity Disclosure [Table]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Underwriters overallotment option.
Underwriters' Overallotment Option
Underwriters Overallotment Option [Member]
Warrants
Warrant [Member]
Two thousand twenty one ATM program.
2021 ATM Program
Two Thousand Twenty One A T M Program [Member]
Stockholders Equity Disclosure [Line Items]
Stockholders Equity Disclosure [Line Items]
Common stock price, per share
Share Price
Underwriting discounts, commissions and offering expenses payable
Underwriting Commissions And Offering Expenses Payable
Net proceeds from sale of common stock after deducting underwriting commissions and offering expenses
Proceeds From Issuance Of Common Stock
Common stock warrants issued
Common stock warrants outstanding
Warrants exercise price per share
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Warrant expiration date
Warrants And Rights Outstanding Maturity Date
Percentage of Commission for shares sold.
Legal expenses incurred.
Percentage of commission for shares sold
Percentage Of Commission For Shares Sold
Legal expenses incurred
Legal Expenses Incurred
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Options to purchase common stock.
Options To Purchase Common Stock
Options To Purchase Common Stock [Member]
Common stock warrants.
Common Stock Warrants
Common Stock Warrants [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti dilutive securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Restructuring liability.
Percent of employees terminated
Restructuring And Related Cost Number Of Positions Eliminated Period Percent
Severance costs and expenses
Severance Costs1
Restructuring liability
Restructuring Liability
Schedule Of Restructuring And Related Costs [Table]
Schedule Of Restructuring And Related Costs [Table]
Restructuring Cost And Reserve [Line Items]
Restructuring Cost And Reserve [Line Items]
Total restructuring charges
Restructuring Charges
Subsequent Event [Table]
Subsequent Event [Table]
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event
Subsequent Event [Member]
Biogen agreement.
Biogen Agreement
Biogen Agreement [Member]
Advisor Agreement.
Advisor Agreement
Advisor Agreement [Member]
Related Party Transaction
Related Party Transaction [Axis]
Related Party Transaction
Related Party Transaction [Domain]
Raymond James and Associates.
Raymond James & Associates
Raymond James And Associates [Member]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Lease Payments Receivable
Lessor Operating Lease Payments To Be Received
Advisory fees payable.
Reimbursement of advisory fee.
Advisory fees payable
Advisory Fees Payable
Reimbursement of advisory fee
Reimbursement Of Advisory Fee
Total expenses